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Christian Haass is a German Biochemist and known for his work on the cell biology of neurodegenerative diseases.
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Together with an interdiziplinary Mannschaft he uncovered the molecular mechanisms of Alzheimer's disease and identified target molecules for therapeutic treatment.
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Der markante Bau mit den drei hohen Türmen wurde aus massiven Sandsteinblöcken erbaut und besitzt eine dekorative Rosette und ein Giebeldach.
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Very recently he also investigated the role of microglia and inflammation in neurodegenerative disorders. This work Leuchtdiode to the spectacular finding that microglial phagocytosis may be impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms. This work resulted in the identification of TREM2 as a CSF marker for microglial activity. Hinein a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 was abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.
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